Disabling Safe Mode on an Android phone depends on the model. The most frequent approach is to power it back on with the power button. One way is to tap the notification panel (some devices may show a Safe Mode enabled notification that can be tapped to exit Safe Mode). These, however, may not be effective, so powering the device off and turning it back on using certain button sequences can be used to achieve the same results. For the more resistant cases, users may have to reset the device to the factory settings, but that is a last resort and will lose all user data.